CINCINNATI -- Jay Bruce's walk-off home run in the 10th inning against Milwaukee right-hander Burke Badenhop lifted the Cincinnati Reds to a 4-3 victory over the Brewers in the opener a three-game series on Friday night at Great American Ball Park.
Badenhop (0-3) allowed Bruce's 11th home run of the season on a 1-2 pitch. It was Bruce's fifth career walk-off home run.
Alfredo Simon (5-2) picked up the victory for Cincinnati.
Martin Maldonado hit a two-out solo homer off Reds starter Bronson Arroyo in the eighth to tie the score.
Arroyo pitched 7 2/3 innings, allowing three runs (two earned) and 12 hits, the second-most in his career.
Milwaukee second baseman Scooter Gennett hit his first major-league home run and left fielder LF Logan Schafer went 3-for-5 with a double.
Brewers starter Kyle Lohse allowed two runs and four hits in the first two innings but shut down his former team in the next four innings, retiring 11 straight in one stretch. Lohse worked six innings, allowing three runs (one earned) and five hits.
With the score tied 2-2 in the sixth, Cincinnati's Todd Frazier appeared to be caught stealing after a leadoff single, but Milwaukee first baseman Yuniesky Betancourt's throw to second caromed into center, allowing Frazier to reach third. He scored moments later on Jack Hannahan's sacrifice fly.
The teams combined for five errors, including three by the usually sure-handed Reds.
Milwaukee loaded the bases after Maldonado's tying homer in the eighth, but Reds reliever Sam LeCure got Jean Segura to pop out to second baseman Brandon Phillips to end the inning.
The Reds' Shin-Soo Choo doubled leading off the game and stole third. The Brewers chose to play the infield in with one out, and Phillips' bloop single over leaping shortstop Jean Segura drove home Choo to put Cincinnati ahead 1-0.
The Reds added a run in the second, but Gennett, who was born in Cincinnati, slugged his first career home run on a 1-1 pitch from Arroyo to make the score 2-1 in the third.
NOTES: Brewers LF Ryan Braun took batting practice before Friday's game, but his sore right hand did not respond well enough for him to avoid missing a fourth straight game. Brewers manager Ron Roenicke indicated before the game that a stint on the disabled list was possible for Braun if an inflamed nerve between his right thumb and index finger didn't improve. .. Reds 1B Joey Votto was given a night off after starting all 67 games this season. Hannahan started at first base for the first time this season. Reds manager Dusty Baker called it a "mental day" for Votto. .. Reds RHP Johnny Cueto threw a successful bullpen session Friday and is on track to start Sunday. Cueto, who has been on the DL with a strained right lat muscle since June 5, is eligible to be reinstated Sunday, which marks his normal turn in the rotation. .. Cincinnati signed LHP Zach Duke to a minor league contract on Friday. Duke was released by the Washington Nationals on June 9.