TORONTO -- Will Middlebrooks hit three home runs, two of them against knuckleball pitcher R.A. Dickey, and the Boston Red Sox used six homers in all to defeat the Toronto Blue Jays 13-0 on Sunday before a crowd of 41,168 at Rogers Centre.
Middlebrooks also had a double in going 4-for-5 with four RBI in the first three-homer game of his career. He hit a fly out to the warning track in his final at-bat.
Daniel Nava, Jacoby Ellsbury and Mike Napoli also homered for the Red Sox, all against right-handed reliever David Bush who gave up Middlebrooks' third of the game. Napoli also had four runs batted in.
Left-hander Jon Lester (2-0) held the Blue Jays to five hits while striking out six in seven innings. He has won both of his starts this season and is 12-7 in 23 career starts against Toronto.
The Red Sox rapped out 10 hits and scored eight runs (seven earned) against Dickey (0-2) in 4 2/3 innings to take the rubber match of the three-game series between American League East rivals.
Dickey allowed five runs before he retired a batter in the game that ended a disappointing season-opening home stand for the Blue Jays (2-4).
The Red Sox (4-2) play their home-opener Monday against the Baltimore Orioles.
The first five Red Sox batters of the game scored. Jacoby Ellsbury and Napoli doubled, Shane Victorino and Dustin Pedroia singled and Middlebrooks hit a two-run homer. Napoli's double also scored two runs. The first two outs in the first were on fly balls to the warning track.
After giving up an infield single in the second, Dickey retired the next three batters in the inning, two on strikeouts.
The Red Sox scored an unearned run in the third. Middlebrooks doubled with one out, took third on Henry Blanco's passed ball and scored on Nava's sacrifice fly.
Middlebrooks hit his second homer of the game on a 3-2 count to lead off the fifth.
Dickey was replaced by Bush after a two-out walk in the fifth inning. Bush was called up from Class-AAA Buffalo on Saturday and he allowed five runs on four home runs, a single and a walk in three innings.
Bush gave up back-to-back homers to Middlebrooks and Nava to open the seventh and in the eighth allowed homers to Ellsbury and Napoli. Left-hander Brett Cecil replaced him in the eighth.
Clayton Mortensen replaced Lester in the eighth.
NOTES: Blue Jays right fielder Jose Bautista (twisted right ankle) did not start for the third game in a row but was available to pinch hit. He is expected to play Tuesday in Detroit after Monday's off-day in the schedule. ... Red Sox DH David Ortiz (right Achilles) is scheduled to start at extended spring training Monday and in about three days begin a minor-league rehabilitation assignment. ... Boston shortstop Jose Iglesias was back in the lineup Sunday after sitting out Saturday with a bruised arm after being hit by a pitch in Friday's game. ... The Blue Jays started switch-hitting Emilio Bonifacio in center field for Sunday's game and sat left-handed hitting Colby Rasmus against Lester. ... With Blanco catching, J.P. Arencibia was used as DH. ... A fan ran on the field and slid into second base in the top of the eighth. He was caught by security as he tried to climb the center-field wall.