Instead, they again lost to the lowly Texas Rangers.
Seattle will try to bounce back and remain in playoff position when these AL West rivals continue a three-game series Tuesday night.
Cano left in the third inning of Sunday's 8-6 win against Boston, Seattle's 14th in 18 games, with dizziness from an illness. The second baseman, the AL's fourth-leading hitter at .326, was back in the lineup Monday but couldn't lead the Mariners (71-59) to a ninth win in 10 home contests.
Cano had one of Seattle's four singles in a 2-0 loss, its eighth in 13 games this season against Texas (51-79), and committed an error in the seventh inning that led to the second run.
The Mariners, now one-half game in front of Detroit for the second wild card, have losing records against only two other AL teams, Baltimore (2-5) and Minnesota (2-5).
"They got pitching and we (were) able to take advantage of some things that we created, and we just got to continue to do that," Rangers manager Ron Washington said.
Seattle's James Paxton (3-1, 2.20 ERA) will try to bounce back from his first defeat in 10 major league starts. He gave up four runs in a career-low four innings in Wednesday's 4-3 loss to Philadelphia, but three were unearned because of a throwing error the left-hander committed in his final inning.
"Obviously that can't happen, you've got to be able to make the throw to first," said Paxton, who will be facing Texas for the first time. "Something that I'll definitely work on between starts."
The Rangers, owners of MLB's worst record, will seek their first three-game win streak since June 11-14 and a season high-tying third in a row on the road.
Nick Martinez (3-9, 5.13) is looking to earn his third victory in four starts and win consecutive outings for the first time in his career. The rookie right-hander gave up two runs in six innings and struck out a career-high seven Wednesday in a 5-4 victory in Miami.
Martinez was 1-8 with a 7.01 ERA in his previous 12 starts.
He gave up two runs in six innings in his only start against Seattle on June 15, a 5-1 defeat. Kyle Seager went 3 for 3 against him and is batting .390 with nine homers in his last 34 games against Texas.
Rangers outfielder Leonys Martin, batting .432 in his last 12 games, is hitting .355 in his last 10 against Seattle.