McFadden was ruled out on Friday because of a hamstring injury and the team announced Saturday that Pryor would miss the game because of a sprained right knee. Undrafted rookie free agent Matt McGloin will start at quarterback and Rashad Jennings will start at running back.
Oakland right tackle Tony Pashos was active after missing four of the last five games with a hip flexor.
Houston will be without cornerback Kareem Jackson, who has a chest injury. Also inactive for the Texans are quarterback T.J. Yates, cornerback Elbert Mack, linebackers Joe Mays and Mike Mohamed, guard Cody White and tight end Ryan Griffin.
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- Darren McFadden