Kelly, Pearce, Mariappa, Harte
Guthrie, Leigertwood, Karacan
Robson-Kanu, Pogrebnyak, McAnuff
Clyne, Yoshida, Hooiveld, Shaw
Puncheon, Cork, Schneiderlin, Davis
Reading is likely to welcome back Adam Federici from an ankle injury, but the clash comes too soon for Jimmy Kebe, who misses out with a groin strain. Jason Roberts remains out for the season after undergoing surgery on a hip complaint last month.
Contrary to its opponents, Southampton arrive at the Madejski Stadium largely in rude health.
However, Mauro Pochettino will be forced to sweat on the fitness of key playmaker Adam Lallana (groin) and defender Danny Fox (hip) but will most likely welcome back Artur Boruc, who has been training since Monday after being withdrawn against Chelsea due to a virus.
Gaston Ramirez was an unused substitute last time out after a late arrival back from international duty, but is expected to return to contention on Saturday.