SAN DIEGO -- Domonic Brown homered and tied his career high with four RBIs, and the Philadelphia Phillies recorded a 6-2 victory over the San Diego Padres at Petco Park on Tuesday night.
Brown, who went 1-for-4 with a walk, drilled a three-run homer off Jason Marquis in the third inning, giving the Phillies a 3-2 lead they would not surrender. The long ball was Brown's 20th of the season, also a career best.
Marquis walked Brown with the bases loaded in the fifth.
It was the fifth time Brown has driven in four runs in a game, the last occurring June 2 in a win over the Milwaukee Brewers.
Marquis had his string of consecutive wins snapped at eight. He hadn't dropped a decision since April 22, when he lost to Milwaukee. The Phillies tagged Marquis (9-3) for six runs on six hits in 4 1/3 innings. Marquis, who entered the game with a 6-8 record and a 5.45 ERA in his career against the Phillies, walked five and struck out four.
Kyle Kendrick (7-4) allowed two runs and scattered seven hits over eight innings. He struck out six and walked none. Reliever Antonio Bastardo gave up two hits in the ninth before striking out Logan Forsythe for the final out.
The Phillies (37-41) have captured 25 of the 32 games they've played at Petco Park since it opened in 2004. The Padres (39-39) lost for the third time in their past four contests.
Kyle Blanks, who had a career-high four hits in Monday's win over the Phillies, including the game-winner, led off the second with a single to left and advanced to third on a double by Yasmani Grandal. Blanks scored on a groundout by Alexi Amarista for a 1-0 San Diego lead.
Pedro Ciriaco followed with an RBI single to left, scoring Grandal for a 2-0 Padres lead with one out.
Brown jumped on a 2-0 fastball from Marquis and launched it deep into the seats in right for a three-run homer with two outs in the third to put the Phillies on top.
The Phillies added three more runs in the fifth. Brown's bases-loaded walk scored Jimmy Rollins and chased Marquis, and then a wild pitch by reliever Brad Brach brought home Chase Utley.
A sacrifice fly by John Mayberry scored Ryan Howard for a 6-2 Phillies advantage.
NOTES: Howard returned to the lineup Tuesday after sitting out Monday's game with a sore left knee. The Phillies first baseman was batting .432 with three home runs and 11 RBIs over his last 12 games before going 0-for-4 Tuesday. ... Padres 2B Jedd Gyorko, who is eligible to come off the disabled list, flew to Double-A San Antonio on Tuesday and will play there in rehab games Wednesday and Thursday. Gyroko, out due to a right groin strain, probably will be activated Friday when the Padres open their upcoming road trip in Miami. ... LHP Robbie Erlin (1-0), whom the Padres called up from Triple-A Tucson, will start against Phillies LHP Cole Hamels (2-11) on Wednesday. ... Rollins and Utley played their 1,000 game together Monday. ... The game drew a crowd of 24,695.