SAN DIEGO -- Jesus Guzman's RBI single in the 17th inning lifted the San Diego Padres to a 4-3 victory over the Toronto Blue Jays before a crowd of 24,219 at Petco Park on Friday night.
Clayton Richard (1-5) ended his five-game skid with the win. Todd Redmond (0-1) was dealt the loss.
Toronto's Edwin Encarnacion hit his team-leading 15th home run of the season and Colby Rasmus launched his ninth, but it didn't matter in the end.
San Diego starter Jason Marquis allowed three runs and seven hits, including two home runs, in 5 1/3 innings. He struck out six and walked four. Marquis retired the Blue Jays in order in the first, but they consistently knocked him around from that point on.
Toronto rookie Chad Jenkins, making only his third big league start, worked five innings, giving up three runs (two earned) and three hits with two strikeouts and no walks. He hit Carlos Quentin with a pitch in the fifth.
Padre first baseman Yonder Alonso also was hit by a pitch on his right hand by reliever Aaron Loup in the seventh and left the game in the eighth. He suffered a hand contusion. X-rays were negative. Alonso will be re-evaluated on Saturday.
The Padres (25-29) handed the Blue Jays (23-32) their second straight loss.
With one out in the second inning, Colby Rasmus jumped on the first pitch he saw from Marquis after a walk to J.P. Arencibia and drove it an estimated 409 feet over the wall in center for a two-run homer.
In the bottom of the inning, Rasmus robbed Alonso of a home run by leaping and making a catch at the center-field wall.
Encarnacion led off the fourth by drilling Marquis' first pitch onto the lower level patio of the Western Metal Supply building in left for a 3-0 Toronto lead.
The Blue Jays threatened again later in the inning, loading the bases. But Marquis struck out Jenkins to escape the jam.
The Padres rallied to tie the score at 3 in the fifth on Jedd Gyorko's two-run double to right-center, scoring Quentin and Alonso. Gyorko, who advanced to third on the throw to the plate, came home when Arencibia's attempt to throw him out at third sailed past Encarnacion and down the left-field line.
NOTES: Encarnacion's homer ended a two-game drought by the Blue Jays. ... Marquis made his 300th career start, one of 20 active pitchers to have 300 or more starts. ... This is the third series between the two clubs, all of them played in San Diego. The Padres, who had lost four of six to the Blue Jays entering Friday's game, have never played in Toronto, the only major league city they have failed to visit. ... The Padres honored several former Negro League players, including country and western singer Charley Pride, during its 10th "Salute to the Negro Leagues" before the game. The others included George "Jo-Jo" Altman, Neale "California Comet" Henderson, Don "Groundhog" Johnson, Ray "Boo Boy" Knox, Minnie Minoso, Mack "The Knife" Pride, Jim Robinson and Ron "Roomie" Teasley.