Matthews is expected to play with a club on his right hand after missing four games with a thumb injury. Perry has missed three games with a foot injury.
Guard T.J. Lang is active after leaving last week's loss to the Bears with a concussion.
Eagles quarterback Michael Vick is inactive a second straight week with a hamstring injury. Nick Foles is starting a week after throwing seven touchdown passes in a win over Oakland.
Philadelphia will also be without starting cornerback Bradley Fletcher (pectoral muscle).
As expected, Seneca Wallace is starting at quarterback for the Packers with Aaron Rodgers out with a left collarbone injury.
AP NFL website: www.pro32.ap.org
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