With Cristiano Ronaldo among a host of names missing out due to suspension, los Blancos were decidedly off-color in front of goal, and struggled to create many meaningful moments in the face of a determined rearguard effort from the hosts.
Substitute Kaka's 76th minute red card effectively ended any hopes of a victory for Madrid, who could see their gap to league leaders Barcelona grow to 19 points should the Catalans triumph against Malaga on Sunday.
It took the visitors the best part of half an hour to register their first real chance. Andres Fernandez rashly strode off his line to confront Higuain, who beat him to the byline, but saw his cross towards an empty net hacked away from danger by Alejandro Arribas.
Madrid seemed unable to find any conventional route through to goal, and it took an unorthodox header from Callejon that looped onto the roof of the net for them to threaten the home side again.
Osasuna were generally comfortable defending against the capital outfit, and managed to create some danger of their own at the other end of the pitch when Alvaro Cejudo smashed a half volley just over the bar after combining well with Emiliano Armenteros.
But Madrid would spur a great opportunity to break the deadlock on the stroke of halftime. Fernandez was caught out of position again, this time by Callejon, who teed up Fabio Coentrao at the edge of the area, but the Portuguese drove his finish wide of the far post.
Osasuna went close barely a minute into the second half, as Kike Sola cut in off the left flank to force Casillas into his first save of the match with an awkward parry.
And as the second half wore on, the hosts continued to look capable of repelling the threat posed by Madrid, who were having a tough time breaking through their ranks.
Kaka and Karim Benzema entered the fray just before the hour mark, and the Brazilian picked up a booking within minutes of his introduction for a flying tackle on Oier.
And that infraction would come back to haunt him in the 76th minute, as he was shown his second yellow card after reacting angrily in a confrontation with a few Osasuna players, reducing Madrid to ten men.
The dismissal effectively signaled the end of Madrid's ambitions for all three points, as it was forced to hang on for the remainder of the match to limp towards a point that it barely deserved.
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