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Orioles 10, Blue Jays 8

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TORONTO -- Designated hitter Nelson Cruz hit two home runs, including a grand slam in a six-run fifth inning, and the Baltimore Orioles defeated the Toronto Blue Jays 10-8 on Wednesday night.

The five-RBI game boosted Cruz's season total to 21 RBIs and six home runs.

First baseman Chris Davis and catcher Matt Wieters also homered for the Orioles (10-10), who trailed 6-1 after the Blue Jays' six-run second inning.

The Blue Jays (11-10) had a three-run homer from third baseman Brett Lawrie, a two-run blast from shortstop Jose Reyes and solo shot from second baseman Ryan Goins.

Right-hander Chris Tillman (3-1) picked up the win despite allowing nine hits, including three homers and seven runs in 5 2/3 innings. Right-hander Tommy Hunter pitched the ninth for his sixth save of the season despite loading the bases on three singles. The game ended on a double play.

Right-handed reliever Todd Redmond (0-2) allowed four hits, including Cruz's grand slam, and three runs in two-thirds of an inning to take the loss.

Right-hander Dustin McGowan, who started for Toronto, allowed five hits, including two home runs, one walk and six runs while striking out five in five-plus innings.

Goins hit his first homer of the season in the sixth to cut Baltimore's lead to 9-7.

Wieters hit his fourth homer of the season against left-hander J.A. Happ in the seventh to restore a three-run lead.

Pinch-hitter Josh Thole singled in a run against right-handed reliever Darren O'Day in the home half of the seventh to trim the lead to 10-8. Left-hander Brian Matusz started the inning and allowed two singles.

Davis hit his second homer of the season with two out in the first inning.

Lawrie, who had a three-run homer in the eighth of Tuesday's 9-3 win, hit a three-run homer to key Toronto's six-run second.

First baseman Juan Francisco led off the inning when he was hit by a pitch and took third on a single by catcher Dioner Navarro. Francisco was out going home on a comebacker to Tillman by center fielder Colby Rasmus. Lawrie followed with his fifth homer of the season.

Second baseman Ryan Goins walked and Reyes hit his first homer of the season for a 5-1 lead. Left fielder Melky Cabrera singled, right fielder Jose Bautista walked and designated hitter Edwin Encarnacion singled for a 6-1 lead.

The Orioles scored twice in the third. Second baseman Jonathan Schoop led off with a double and scored on a single by right fielder Nick Markakis, who was picked off first. Cruz hit his fifth homer of the season.

The Orioles loaded the bases with none out in their six-run fifth. Third baseman Ryan Flaherty walked, Schoop hit an infield single and left fielder David Lough was hit by a pitch.

Right-hander Todd Redmond replaced McGowan and retired Markakis before giving up the second homer of the game and the sixth of the season by Cruz.

Cruz's seventh career grand slam gave Baltimore a 7-6 lead.

The Orioles tacked on two more runs on a double by Wieters and a sacrifice fly by shortstop J.J. Hardy before left-hander J.A. Happ took over.

NOTES: Orioles C Matt Wieters (sore right forearm) was back in the lineup on Wednesday after missing two games. ... Orioles SS J.J. Hardy (right hamstring strain) was back in the lineup on Wednesday after missing two games. He came out of Sunday's game at Boston in the sixth inning. ... The Blue Jays hit three, three-run homers in Tuesday's 9-3 win. It was the first time they had hit three homers in one game since Aug. 20, 2010, and the fourth time in club history. ... RHP Bud Norris (0-2, 4.42 ERA) will start Thursday for the Orioles in the finale of the three-game series and the Blue Jays will start RHP Drew Hutchison (1-1, 3.60 ERA).

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