Art Bernardi scored 14 points and Tyler Russell had 12 for the Huskies (4-7), who made just one of their first 21 attempts from the field in the second half.
Oregon made quick work of Houston Baptist, jumping out to a 17-4 lead in the opening 5:20.
Singler had seven points during that stretch, forward Arsalan Kazemi had four assists on the Ducks' first six baskets, and Oregon outrebounded the Huskies 18-2 at one point.
Oregon put the game out of reach with a 12-0 run late in the first half that included back-to-back 3-pointers from Singler to give the Ducks a 40-12 lead.
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