EUGENE, Ore. -- On a night when No. 3, No. 4, and No. 5 were defeated, No. 2 Oregon had no trouble avoiding an upset. The Ducks jumped on No. 23 Washington from the start, taking a 21-0 lead after the first quarter and stretching it to 35-7 by halftime before finishing off a 52-21 win Saturday night at Autzen Stadium. While Florida State, LSU and Georgia all dropped off the list of unbeatens earlier in the day, Oregon improved to 6-0 and cemented itself at No. 2 behind Alabama in the polls midway through the regular season. The Ducks piled up 319 yards of offense in the first half to pull away from the Huskies. Oregon (6-0, 3-0 Pac-12) added on in the third quarter when Rob Beard booted a 28-yard field goal to put the Ducks ahead 38-7. Washington's Bishop Sankey answered with a 6-yard touchdown run to get the Huskies within 38-14 with 2:56 left in the third quarter. Oregon quarterback Marcus Mariota responded with his fourth touchdown pass of the game, a 14-yarder to Colt Lyerla to push the lead back to 45-14 on the first play of the fourth quarter. Oregon freshman Byron Marshall added a 4-yard touchdown run to increase the lead to 52-14. Mariota was 15-for-24 for 198 yards and four touchdowns, while Kenjon Barner ran 20 times for 122 yards for the Ducks. Sankey gained 104 yards on 25 carries to lead the Washington offense. Huskies quarterback Keith Price completed 19 of 31 passes for 145 yards. He was intercepted twice. Mariota threw three touchdown passes in the first half to help Oregon take a 35-7 halftime lead. Oregon scored first after Washington's Marvin Hall fumbled a punt, giving the Ducks the ball at the Huskies' 20-yard line. Two plays later, Oregon's De'Anthony Thomas scored on a 16-yard run to put Oregon ahead 7-0 midway through the first quarter. Oregon put together a longer drive for its second score of the first quarter, going 80 yards on four plays in just 1 minute, 3 seconds. Mariota threw a 48-yard pass to Lyerla, then found Keanon Lowe for a 21-yard touchdown on the next play. On Washington's next possession, Avery Patterson intercepted a pass and returned it 43 yards for a touchdown to put the Ducks ahead 21-0. Washington cut the lead to 21-7 early in the second quarter when Sankey scored on a 1-yard touchdown run. Oregon answered right away when Mariota threw a 10-yard touchdown pass to Lyerla. The Ducks stretched the lead to 35-7 midway through the second quarter when Mariota completed a 34-yard TD pass to Josh Huff. NOTES: Oregon linebacker Michael Clay, who was injured last week against Washington State, did not play against the Huskies. ... Lowe, who caught a touchdown pass in the first quarter, originally committed to play at Washington before signing with Oregon out of Portland's Jesuit High School. ... Oregon has returned four interceptions for touchdowns in its last three games. The last time the Ducks returned four interceptions for touchdowns in a season was 1991.