DENVER -- The Denver Nuggets couldn't buy a basket in the first quarter. Once they found their rhythm, there was nothing the short-handed San Antonio Spurs could do about it.
Wilson Chandler had a game-high 29 points, Corey Brewer scored 28, and Denver overcame a sluggish start to beat the Spurs 96-86 on Wednesday night at Pepsi Center.
Andre Iguodala had a triple-double with 12 points, 10 assists and 13 rebounds for the Nuggets, who set a franchise record with their 21st straight home win. They also moved closer to clinching home-court advantage in the first round with a week left in the season.
"That's the main goal, getting the No. 3 seed and having home-court advantage," Chandler said.
Tim Duncan and Gary Neal had 17 points each for San Antonio.
The Spurs (57-21) are battling for the top seed in the Western Conference without two of their top players. Point guard Tony Parker was out with a sore neck, and Manu Ginobili missed his fifth straight game with a right hamstring strain.
Nando de Colo and Danny Green started in their place, but they couldn't stop the Spurs from falling into a tie with Oklahoma City for the conference's best record.
"The guys we have here, we have to be focused and ready to play," San Antonio guard Cory Joseph said.
The Nuggets are also battling injuries while fighting for a top-four seed. Ty Lawson missed his fifth straight game with a strained right heel and a tear in the plantar fascia on his right foot, and Danilo Gallinari is done for the year after tearing the anterior cruciate ligament in his left knee a week ago.
Things could have gotten worse for Denver when Kenneth Faried lay on the court after a flagrant foul on Patty Mills in the second half. Faried finally got up and continued to play.
Late in the game, Faried took an elbow to the head and walked gingerly off the court. Faried said he was fine and would play Friday in Dallas.
Despite the injuries, the Nuggets (54-24) keep winning and are on track for the No. 3 seed in the West. They are two games ahead of the Los Angeles Clippers with four games left.
Denver overcame some early struggles Wednesday to win for the 20th time in its past 22 games and tie the franchise record for home wins (36) and overall wins in a season (54).
"I hope we can make it 57 or 58," Nuggets coach George Karl said.
While their home winning streak looked in jeopardy early, the Nuggets put this one away in the fourth. Leading 69-63, Denver had three steals to spark a 13-0 run that forged an 82-63 advantage with 8:08 left.
San Antonio missed three consecutive 3-pointers to start the period, part of a 4-for-21 night from behind the arc.
"When you don't make shots, it's pretty easy to fast-break the way they did," Spurs coach Gregg Popovich said. "When you're that bad from the 3-point line and you turn it over at the same time, people make runs."
With Duncan on the bench the entire fourth quarter, San Antonio got within five with 1:33 left, but Denver closed it out.
"Tonight's game was strange in a lot of ways, but guys kept fighting," Karl said. "Things finally came our way offensively."
The Nuggets started the game with four turnovers and missed their first six shots. The Spurs jumped out to a 14-0 lead, but they couldn't sustain their hot shooting. San Antonio made six of eight shots at the start but then missed 20 of its next 24. Denver rallied to take a 38-37 lead at half.
"They came out, they hit us in the mouth but we're at home," Brewer said. "We were able to get the win."
NOTES: Iguodala's triple-double was his first of the season and ninth of his career. ... The Nuggets nearly tied their season-low point total for a quarter when they scored 11 in the first. Their low is 10 in the third quarter against Memphis on March 15. ... San Antonio forward Boris Diaw will miss two to three weeks with a back injury, Popovich said. ... Popovich said he sat Parker on Wednesday because he wanted him close to fully healthy when the playoffs start in 10 days. "I wouldn't say he's 100 percent thrilled, but at this point I'm a little paranoid with Manu being out and losing Boris for the next two to three weeks," Popovich said. "I'm not going to have the guy who's played the way he's played all year not ready for the playoffs. If I can get him a little bit more rest, that will be in order." ... Lawson practiced with the team Tuesday and Wednesday but wasn't ready to return to action. He has missed eight of the past nine games.