Indianapolis Colts head coach Chuck Pagano has been hospitalized since last Wednesday to be treated for an acute form of leukemia. Pagano has taken an indefinite leave of absence that team owner Jim Irsay and Pagano's doctor believe will last several weeks.
"It's been a very difficult week," Irsay said at a press conference in Indianapolis on Monday to announce Pagano's condition.
Pagano began feeling extreme fatigue during the Colts' bye week and had blood work done to find the cause after the bruising became more prominent and his wife, Tina, encouraged him to seek medical attention.
"I am optimistic," Irsay said. "I feel with every fiber in my body -- Chuck feels the same way -- he can beat this thing."
Offensive coordinator Bruce Arians has been named interim head coach at the recommendation of Pagano and said he began preparation for Sunday's game with the Packers with that in mind. Indianapolis started the season 1-2 before a bye last week. The staff structure was endorsed by Irsay and general manager Ryan Grigson.
It's unlikely Pagano will return and be "all in," Irsay said, in a coaching capacity this season because of the peaks and valleys that come with recovery.
---Center A.Q. Shipley was signed by the Indianapolis Colts off their practice squad. The Colts also waived outside linebacker Mario Addison from the 43-man roster and released D.J. Johnson from the practice squad, replacing him with fellow cornerback Marshay Green.
---Denver Broncos center J.D. Walton is out for the year after the team placed him on injured reserve Monday, a day after he broke an ankle during a 37-6 rout of the Oakland Raiders.
Walton left late in the first half and was replaced by veteran Dan Koppen.
---New York Jets wide receiver Santonio Holmes will miss multiple games because of a left foot injury, ESPN New York reported Monday.
Holmes sustained the injury during Sunday's 34-0 loss to the visiting San Francisco 49ers. X-rays were negative. He had an MRI Monday morning but coach Rex Ryan said he did not have the results.
Holmes may seek a second opinion. Ryan said doctors have not determined whether there is muscle or ligament damage but an Achilles tendon injury has been ruled out.
---The New York Jets signed cornerback Aaron Berry to a two-year contract Monday, according to ESPN.
Berry, who was waived by the Detroit Lions during the summer following two arrests, served a three-game suspension by the NFL.
The Jets need help at corner with Darrelle Revis likely out for the rest of the season with an ACL tear. Running back Joe McKnight had even suited up as a defensive back for depth.
---Philadelphia Eagles quarterback Michael Vick has a knee bruise but will play this Sunday at the Pittsburgh Steelers.
Eagles coach Andy Reid made the announcement to reporters on Monday.
---The New York Giants do not know yet how long they will be without cornerback Kenny Phillips, who left Sunday night's game in the first quarter with a knee sprain.
Phillips was able to walk to the locker room on his own after the injury.
The Giants have had a host of injuries in their defensive backfield. Terrell Thomas is out with an ACL injury and Jayron Hosley and Michael Coe were inactive with hamstring injuries.
Safety Antrel Rolle played despite being questionable with a knee injury.
---The Philadelphia Eagles' 19-17 victory over the New York Giants on Sunday night registered a 15.6 overnight rating and a 25 share, according to NBC.
The rating is 23 percent higher than last year's Week 4 "Sunday Night Football" broadcast of the Jets-Ravens and marked the best overnight rating for a Week 4 primetime game in 16 years.
---Pittsburgh Steelers running back Rashard Mendenhall is expected to return from an ACL injury this Sunday against the Philadelphia Eagles, ESPN.com reported Monday.
The Steelers could use a healthy Mendenhall as they come off a bye averaging just 65 rushing yards a game and 2.6 yards per carry, both rank 31st in the NFL.
---Dallas Cowboys outside linebacker Anthony Spencer will not play Monday night against the Chicago Bears because of a strained pectoral muscle, according to ESPN Dallas.
Spencer, who was held out of practice last week, is listed as questionable on the team's injury report.
Victor Butler will start in place of Spencer.
---Chicago Bears running back Matt Forte will be a game-time decision to play against the Dallas Cowboys on Monday night as he continues recovering from a sprained ankle.
Forte was injured against the Green Bay Packers on Sept. 13 and has missed one game. He practiced on Saturday after getting limited work most of lat week.
---An MRI on Detroit Lions defensive end Cliff Avril on Monday revealed there is no serious damage to his back, according to CBS Sports.
Avril left Sunday's game in the fourth quarter after twisting his back. He said he expects to be fine. The Lions have a bye this week and then visit the Philadelphia Eagles on Oct. 14.
---The Buffalo Bills will probably be without starting offensive linemen Cordy Glenn and Kraig Urbik for this Sunday's game at the San Francisco 49ers, according to ESPN.com.
Both injuries occurred during the Bills' 52-28 loss to the New England Patriots on Sunday.
Left tackle Glenn injured an ankle in the third quarter and right guard Urbik sustained a high right ankle sprain.
--- Members of the Houston Texans accused Tennessee Titans tackle David Stewart of employing some dirty tactics during their game on Sunday, including pulling the hair of Houston linebacker Brooks Reed, the Houston Chronicle reported.
"I saw some things I've never seen before," Texans defensive end Antonio Smith told the Chronicle. "I saw him try to pull (Reed's) hair out, tried to ride somebody's back, which I thought was kind of funny, actually."
The 6-foot-7, 315-pound Stewart is in his eighth NFL season.
--- Matt Hasselbeck is expected to replace injured Jake Locker as the Tennessee Titans' starting quarterback for this week's game against Minnesota, CBSSports.com reported Monday.
Locker underwent an MRI on his injured right shoulder on Monday and is expected to miss at least a week or two, according to the report.
The extent of the injury is still not completely known.