Myers connected off CC Sabathia for a three-run shot in the third inning Sunday.
With runners at first and second, the 2013 AL Rookie of the Year sent a long drive to right-center beyond the reach of Jacoby Ellsbury. The ball hit the top of the wall near the 385-foot sign, caromed off a leaping Ellsbury and rolled away along the warning track.
Myers jogged out of the batter's box, then turned it on while rounding first base. He scored standing up without a play after second baseman Yangervis Solarte couldn't handle a one-hop throw from right fielder Carlos Beltran.
It was Tampa Bay's 11th inside-the-park homer and first since Ben Zobrist did it against Toronto at Tropicana Field on Sept. 25, 2011.
The previous player to hit an inside-the-park home run at Yankee Stadium was Derek Jeter against Kansas City on July 22, 2010, according to STATS.