Richard Ross added 12 points, eight rebounds and three blocks for Old Dominion (15-16, 9-7 Conference USA), which finished the first half on a 7-1 run and extended it to 21-4 early in the second for a 42-24 lead with 14:50 to play.
East Carolina (16-15, 5-11) answered with four straight points to close the deficit to 14 and that was as close as it would get.
Caleb White had 12 points and Paris Roberts-Campbell added 10 for ECU. White was 5 of 15 from the field and Roberts-Campbell was 2 of 10.
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