The Revolution haven't beaten the Rapids since 2007, and they haven't done so in Colorado since 2002. Colorado leads the all-time record by 18 to 11, with nine draws. The teams tied in both meetings last season.
New England, seven points from six games, has lost three games in a row, the most recent a 1-0 reverse to the New York Red Bulls.
The Rapids put an end to a three-game losing skid of their own in emphatic fashion on Saturday, racking up the score late in a 4-0 win over Chivas USA. Colorado has 12 points from eight games.
Former Rev Jeff Larentowicz, who recently signed a contract extension with Colorado, is two bookings away from a suspension for yellow card accumulation.
New England's Fernando Cardenas, John Lozano and Colorado's Luis Zapata all featured on the 2009 Deportivo Pereira roster, in Colombia.
Conor Casey didn't travel with the Rapids for this match. The U.S. international made a return from an Achilles injury last week, appearing as a substitute in stoppage time against Chivas USA, but coach Oscar Pareja decided to let the burly striker train at home rather than subject him to midweek travel and the turf of Gillette Stadium.