Leonard Washington added 10 points and the Cowboys (17-4, 3-2 Mountain West) shot 65.8 percent from the field while handing Boise State its sixth straight loss.
Joe Hanstad scored 13 points, Ryan Watkins added 12 and Tre' Nichols scored 11 for the Broncos (10-10, 0-5).
Wyoming's lead was 53-31 after Washington's three-point play with less than 11 minutes left.
The Cowboys were 8-of-14 from 3-point range, hitting four in each half.
Wyoming never trailed and took an early 12-4 lead after back-to-back 3-pointers by Cruz and Washington. The Cowboys led by as many as 15 in the half and shot 63.2 percent en route to a 33-20 halftime lead.
Boise State is still seeking its first victory as a member of the Mountain West.
- Sports & Recreation/Basketball
- Sports & Recreation
- Boise State
- Mountain West