NEW YORK -- Veteran left-hander Andy Pettitte left Thursday night's game against the Seattle Mariners with a back injury with two outs in the top of the fifth inning and the Yankees were handed a 3-2 loss.
Pettitte was trying to become the 47th pitcher in major-league history to reach 250 victories and gave the Yankees a chance to make that happen by allowing two runs and four hits in 4 2/3 innings.
However, that milestone will have to wait after Pettitte appeared to wince and hold his right side as he threw a slider to Kyle Seager in the fifth.
Pettitte got a strikeout on the pitch, but Yankees manager Joe Girardi and the training staff came out to check on him. After a brief consultation, Pettitte was lifted from the game as a precaution and the Yankees later announced his injury as a tight left trapezius.
Seattle's starting pitcher also had an injury. Manager Eric Wedge was forced to scratch Aaron Harang after he developed back stiffness on Wednesday that lingered into Thursday. The Mariners started former Yankee Hector Noesi in Harang's place.
Noesi threw 79 pitches in 4 1/3 innings and held the Yankees to one run and three hits. The Mariners successfully navigated the rest of the game with their bullpen.
Oliver Perez, Yoervis Medina, Lucas Luetge and Carter Capps combined to allow one run and four hits in 3 2/3 innings before Tom Wilhelmsen gave up two stolen bases to Brett Gardner in the ninth but retired Robinson Cano for his 11th save in as many opportunities.
Besides the strong relief work, Seattle won for the 12th time in 18 games with the help of RBI singles by Dustin Ackley and Brendan Ryan off Pettitte and a solo home run from Michael Morse in the sixth off Shawn Kelley.
Wedge was ejected for the first time this season for arguing the final out of the second inning.
After Ryan put his hand on his head in disbelief when first-base umpire Hunter Wendelstadt called his fly ball to right field an out, Wedge was ejected, though replays showed that Ichiro Suzuki appeared to get his glove under the ball just before it hit the ground.
Wedge also seemed displeased at a check-swing strike three in the dirt to Raul Ibanez. That came two batters before Ackley's double to right field gave Seattle a 1-0 lead.
The Yankees tied it with an unearned run in the second as Granderson singled and took second on Noesi's throwing error before scoring on a double by David Adams.
Seattle had the bases loaded with two outs in the fourth and took the lead on Ryan's infield hit. The ball went past Adams at third, forcing shortstop Jayson Nix to range to his left into shallow left field.
Noesi was lifted for Perez in the fifth after allowing a one-out single to Chris Stewart that put runners at first and third. The Yankees did not score as Gardner struck out and Nix flied out.
NOTES: The Yankees provided several injury updates. The main news concerned SS Derek Jeter and injured pitchers Michael Pineda and Joba Chamberlain. Four weeks after Jeter suffered another break in his fractured left ankle, the Yankees said it seems to be healing and he could shed his walking boot shortly. "They see the bone is going back together," Girardi said. "They say it's healing. I think he'll be out of the boot sometime shortly and then he'll go from there." As for Pineda (rotator cuff), he will throw 50 pitches on Friday, though the Yankees were uncertain if it would be in extended spring training or an intrasquad game. The Yankees want to build his arm strength back up to 100 pitches but believe he will pitch sometime this year. Chamberlain (rib cage) is eligible to come off the disabled list, but the Yankees are being cautious and giving him another week to throw a bullpen session and possibly make another rehab appearance. ... Wedge said Harang was injured sometime on Wednesday afternoon and described it is as one of those "fluky things." Wedge also said he gave no consideration to moving up rookie RHP Brandon Maurer a day to make the start. ... New York DH Travis Hafner remained out of the lineup with right shoulder soreness but seemed to have no issues while taking batting practice.