Backup quarterback Thad Lewis will make his fourth start of the season in place of rookie EJ Manuel on Sunday when the Buffalo Bills face the Miami Dolphins.
Manuel, the Bills' 2013 first-round draft pick, will sit out after spraining a knee last week. But coach Doug Marrone said Wednesday that Manuel might be able to return for the season finale the following week.
The injury initially was not considered serious, with Marrone saying Monday that Manuel should be OK to play. But Marrone said Manuel's mobility was limited outside the pocket during practice.
The Bills (5-9) are out of playoff contention, but the Dolphins (8-6) are in the thick of the race for a wild-card berth. They trail the Baltimore Ravens by one game for the final AFC spot.
Lewis was signed off the Bills' practice squad in early October and has a 1-2 record as a starter this season. The one win came in Miami -- a 23-21 victory over the Dolphins on Oct. 20.
Lewis has completed 62 of 103 passes for 652 yards with three touchdowns and two interceptions in three games.