After the last undefeated teams in college basketball fell last week, Louisville ascended to No. 1 in the Associated Press rankings on Monday.
The Cardinals (15-1) climbed to the top of the AP poll for the second time in school history. The first came at the end of the 2008-09 season.
Louisville was one of five teams to receive first-place votes. The Cardinals, who have won 10 in a row since losing to previously No. 1 Duke, totaled 65 points in the balloting.
Preseason No. 1 Indiana moved from fifth to second and Duke dropped to third after its loss to North Carolina State on Saturday.
Kansas and Michigan, which suffered its first loss Sunday at Ohio State, rounded out the top five. Each had one first-place vote.
The rest of the top 10 included Syracuse, Arizona, Gonzaga, Minnesota and Florida.