Pierre-Paul hurt a shoulder last weekend against Oakland and did not practice until Friday.
Packers cornerback Sam Shields, who had started every game this season, is not going to play because of a hamstring injury. He was listed as probable Friday despite not practicing.
Scott Tolzien is making his first NFL start for the Packers with Rodgers missing his second game with a fractured collarbone.
Marshall Newhouse replaced Barclay at tackle and Neal started for Perry for the fourth straight week.
Giants running back Peyton Hillis is inactive, replaced by Brandon Jacobs.
AP NFL website: www.pro32.ap.org
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