Jones-Drew has been listed as questionable for Sunday's game with a hamstring injury, which kept him out of last week's loss to Buffalo.
Linebacker Geno Hayes (knee) and defensive tackle Roy Miller (shoulder) are among Jacksonville's seven inactives. Both had been questionable. Linebacker J.T. Thomas and defensive tackle Brandon Deaderick will start in their places.
Receiver Kenny Britt, cornerback Khalid Wooten, linebacker Zaviar Gooden, offensive lineman Kevin Matthews and defensive end Lavar Edwards also are inactive for Tennessee.
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