Jackson, the NFL's active career-leading rusher, missed the past four games with a hamstring injury, but he participated fully in practice on Friday.
Four-time Pro Bowl receiver Roddy White won't play for the second straight game because of ankle and hamstring injuries.
Starting left tackle Sam Baker (knee) and starting linebacker Akeem Dent (ankle) are questionable. Starting defensive tackle Corey Peters (shoulder), cornerback Robert Alford (ankle) and tight end Chase Coffman (ankle) are probable.
The Falcons (2-4) snapped a three-game losing streak last week. Arizona (3-4) has lost two straight.
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