Melvin Ejim had 10 points and 14 rebounds for the Cyclones (19-8, 9-5 Big 12), who've won five straight league games at home for the first time in eight years.
Iowa State cruised past the scuffling Sooners without much help from Royce White, who battled foul trouble and scored just four points. The Cyclones went on a 15-6 run following White's fourth foul with 12:17 left, opening up an insurmountable 18-point lead.
Cameron Clark led five in double figures with 16 points for the Sooners (13-13, 3-11), who've lost six straight and have fallen to .500 for the first time this season.
- Iowa State