Coming into the friendly on the back of a 6-0 thrashing at the hands of Brazil in September, the German is under intense pressure despite having helped the Socceroos already qualify for next year's World Cup.
That huge defeat, combined with Australia's failure at the East Asian Cup and an inability to regenerate an aging squad, have put Osieck in the firing line, with reports suggesting that the Football Federation Australia (FFA) have already begun sounding out potential replacements.
Another heavy defeat could therefore signal the end for Osieck. Indeed, while the Socceroos may be coming up against one of the world's best teams for the second outing in a row, they must avoid embarrassment this time around.
In terms of team news, Brett Holman (quadriceps) and Tom Rogic (groin) have been withdrawn from the squad due to injury. Osieck may decide to give opportunities to fresher faces against France or leave the experimentation until Tuesday's clash with Canada in London.
Veteran goalkeeper Mark Schwarzer has been left out of the squad, and that opens up a position for either Mat Ryan (Club Brugge) or Mitch Langerak (Borussia Dortmund).
Rhys Williams (Middlesbrough), Jason Davidson (Heracles) should get game time, as should Dario Vidosic (Sion) and possibly the likes of Oliver Bozanic (Luzern), Jackson Irvine (Kilmarnock) and Mathew Leckie (Frankfurt).
France coach Didier Deschamps has named a strong squad, as France is still vying for first place in the group and faces Finland in a World Cup qualifier Tuesday. In order to avoid the playoff round, though, Les Bleus will need Spain to trip up against either Belarus or Georgia.
The upcoming matches against Australia and Finland should provide striker Karim Benzema with yet another chance to break his international goal drought. The Real Madrid striker last netted for his country in June last year and could finally be back on the scoresheet playing in front of the likes of Franck Ribery and Samir Nasri.