The Raiders ruled out Pryor on Saturday and announced that undrafted rookie free agent Matt McGloin will start against the Texans.
Pryor had a setback at practice on Friday and had been listed as questionable.
He leads all NFL quarterbacks with 504 yards rushing. But he wore a thick brace over his knee during last week's 24-20 loss to the New York Giants when he was held to a season-low 19 yards on the ground and sacked four times.
McGloin was 7 for 15 for 87 yards in relief of Pryor against the Eagles in Week 9 in his first game action of his career. He will be the 17th quarterback to start for Oakland since the start of the 2003 season.
The Raiders also promoted rookie Tyler Wilson from the practice squad to back up McGloin and waived defensive end Brian Sanford. Wilson was a fourth-round pick but was beaten out for a roster spot by McGloin.
McGloin entered training camp fourth on the depth chart. He was originally a walk-on at Penn State before setting the school record for career touchdown passes.
''What can you say about Matt McGloin? Having been in that league, I know it takes a smart guy, it takes a competitive guy, it takes a guy that does the same thing every day,'' said Penn State coach Bill O'Brien, the former offensive coordinator for the New England Patriots.
''He works at it. He's in the office early, he leaves late. That's what Matt is. Everything Matt gets, he deserves because he works for it. It's going to be fun to watch him play.''
McGloin will start against another undrafted free agent in Houston's Case Keenum. This marks the first time since 2011 that two undrafted free agent quarterbacks started against each other. Kansas City's Tyler Palko faced Chicago's Caleb Hanie on Dec. 4 that year, and Miami's Matt Moore faced Dallas' Tony Romo on Nov. 24.
Disregarding the strike year in 1987, this will be just the second time two undrafted quarterbacks in their first year in the NFL started against each other, according to STATS LLC. The only other time it happened came on Dec. 1, 1985, when Dieter Brock of the Los Angeles Rams faced Bobby Hebert of the New Orleans Saints.
AP Sports Writer Dan Gelston in State College, Pa., contributed to this report
AP NFL website: www.pro32.ap.org
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- Terrelle Pryor
- Oakland Raiders
- Matt McGloin
- Tyler Wilson
- New York Giants