Imes scored on a layup and two 3-pointers in the first 1:40 of the second half to give the Pride (7-22, 4-12) a 38-33 lead after they trailed 31-30 at halftime.
After an Old Dominion free throw, the Pride ran off 10 points for a 50-40 lead with 11:44 left.
Stevie Mejia added 10 points and 10 assists for Hofstra, which had lost 11 of its last 12.
The Monarchs, who shot a season-best 58.9 percent to beat UNC Wilmington on Wednesday night, managed just 37.5 percent (21 of 56) against Hofstra.
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