Stoke (9-10-12) are 10th in the table and have built up a 12-point cushion between themselves and the relegation places after losing just one of their last eight league matches.
The Potters beat West Ham 3-1 at home on Mar. 15 before claiming an impressive 4-1 win at Aston Villa last Sunday. Villa took an early lead before goals from Peter Odemwingie, Peter Crouch, Steven Nzonzi and Geoff Cameron secured Stoke's ninth league win.
Stoke manager Mark Hughes was delighted with his side's display at Villa Park.
"We had a good performance the last time we won away from home a long time ago in August and this performance was certainly on par with anything we have produced home or away this season because of the manner of the result and the margin of victory," Hughes told his club's official website. "We've come to Villa and conceded earlier which we were disappointed about, but that really kicked us into gear to be perfectly honest and from that point onwards we showed purpose and determination to get something out of the game."
Stoke are tough to beat at home and have lost only two of the 15 league matches played at the Britannia.
Hull (9-6-16) may have reached the semifinals of the FA Cup, but they still need points to secure their Premier League status. The Tigers are 13th in the standings and five points above the drop zone.
Steve Bruce's side, who have lost three of their last four league matches, were unlucky to be beaten 2-1 at West Ham on Wednesday evening.
The Hammers took the lead through a Mark Noble penalty after Hull 'keeper Allan McGregor was sent off for bringing down Mohamed Diame. McGregor who saw red for the second time this season was injured in the collision with Diame. Nikica Jelavic equalised for 10-man Hull before an unfortunate own goal by defender James Chester gifted all three points to the Londoners.
Hull boss Steve Bruce hailed his side's performance at West Ham and insisted they deserved a positive result.
"I have to say that with ten men we were totally magnificent," Bruce told his club's official website. "We dominated with ten men. We could have shut up shop and made it one of those horrible games with ten men behind the ball, but we decided to take part in the game and made it a spectacle. We deserved to take something from the game.
"We'll all be looking over our shoulders until we're mathematically safe. But if we keep playing like this, we won't have a problem."
Hull and Stoke played out a goalless draw at the KC Stadium in December in the first meeting between the sides since the Tigers' relegation season in 2009/10.
Stoke will have midfielder Charlie Adam available after a three-match ban, but striker Jon Walters is still suspended. Defender Robert Huth is out for the season after undergoing knee surgery.
Hull will be without McGregor and midfielder George Boyd who is also suspended, while defender Paul McShane (ankle) and midfielder Robbie Brady (groin) are out for the season.