The Texans turned it over two times, managed only 239 yards of offense and were crushed by the Colts, 25-3, at Lucas Oil Stadium.
Case Keenum finished 18 for 34 passing for only 168 yards and no touchdowns and two picks. For the Colts, Andrew Luck wound up 19 for 32 with 180 yards passing, two touchdowns and one pick.
Ben Tate gained 72 yards on 16 carries in addition to three receptions for 20 yards. Ryan Griffin caught six passes for 62 yards.
The Houston defense gave up 152 yards rushing and 180 passing. They brought down Luck for one sack.
Colts running back Trent Richardson racked up 64 yards rushing, 38 receiving and one touchdown. Wide receiver T.Y. Hilton also put together a noteworthy performance with 78 receiving yards.
The Texans are at home to take on the Broncos (11-3) next week while the Colts travel to Kansas City to meet the Chiefs (10-3).
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