Harrison has not played since Pittsburgh's playoff loss at Denver to close last season because of a knee problem that needed surgery during preseason.
Polamalu will miss his second straight game with a calf injury that has not responded well this week.
Running back Rashard Mendenhall, still trying to make his way back from a torn ACL last year, will miss his third straight game.
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Terry McCormick covers the Titans for TitanInsider.comFollow @footballpost on Twitter for the latest news
This story originally appeared on Nationalfootballpost.com
- Pittsburgh Steelers
- James Harrison
- Rashard Mendenhall