Neither had any success, however, last week against Colorado's Jordan Lyles.
The two look to solve Lyles this time around and help the Giants bounce back from a discouraging loss Tuesday night against the Rockies at Coors Field.
San Francisco (75-63) had a golden opportunity to make up extra ground in the NL West race on Monday. It defeated the Rockies 4-2 in a game resumed after being suspended on May 22 because of rain and then built a 7-2 lead after five innings in the day's regularly scheduled contest. Colorado (55-83) rallied to take a 9-7 lead into the ninth before the Giants scored twice to tie it.
Charlie Blackmon then drove in the winning run with a two-out single in the ninth to hand the Giants a 10-9 loss and snap their six-game winning streak.
''Hard-fought game, tough game,'' manager Bruce Bochy said.
Despite the loss, Pence and Posey remained locked in.
Pence, who delivered a tiebreaking double in the eighth inning of the suspended game, hit a three-run homer later in the scheduled contest. He is batting .393 with 14 RBIs during a 14-game hitting streak, and .451 with five homers and 12 RBIs while hitting safely in 14 in a row against the Rockies. The NL leader with 166 hits is also batting a major league-best .528 (19 for 36) with runners in scoring position since the All-Star break.
Posey has also been a threat with men in scoring position, hitting .419 (13 for 31) in such situations since the break. He had three hits and drove in a run Monday, and is batting .469 with five homers and 14 RBIs in his last 11 games.
Like Pence, he's also putting up gaudy numbers against Colorado, hitting .429 with four home runs and 11 RBIs in his last nine in the series.
While Pence and Posey have been routinely frustrating pitchers over the past few weeks, the duo went a combined 0 for 5 against Lyles (6-2, 4.08 ERA) on Thursday.
Although Lyles managed to shut down the two, the right-hander allowed three runs and four hits in six innings and was saddled with a 4-1 loss.
His biggest moment came at the plate, as his two-out double in the third inning snapped Yusmeiro Petit's major league record of 46 consecutive batters retired. Petit (4-3, 3.44 ERA), who'll be opposing Lyles again, set the record one batter earlier.
Petit, whose streak covered eight games with six coming in relief, made the start in place of the struggling Tim Lincecum. After yielding a run and four hits in six innings to get the win, Bochy has decided to stick with him.
The righty struck out nine and walked none, raising his totals to 48 strikeouts to just four walks over 37 1-3 innings in his last 16 outings.
Colorado broke out of its offensive funk Monday, pounding out 15 hits after averaging 1.5 runs while batting .144 in dropping five of its previous six.
Michael McKenry had three hits and scored twice after going 1 for his previous 17, while Josh Rutledge had three hits, two RBIs and three runs after going 1 for his prior 18.
''The hits were coming from a lot of guys you may not expect it from,'' said Blackmon, who was 0 for 5 before his walkoff hit. ''It's really positive to see that kind of contribution from not the usual suspects.''
The status of San Francisco's Michael Morse is uncertain after he experienced soreness on his left side in batting practice Monday.