San Francisco 49ers (5-2) at Jacksonville Jaguars (0-7)
Sunday, 1:00 p.m. ET, at Wembley Stadium, London - TV: FOX
*TV announcers: Chris Myers, Tim Ryan, Jennifer Hale
*Keys to the game: The concept is simple: keep the game close and run, run, run. The problem for the Jaguars is they have been outscored by a staggering 146 points through six losses - an average of 24.3 per game. When you're constantly trying - unsuccessfully - to dig out of double-digit holes and opponents average nearly seven minutes more per game in time of possession, it's difficult to establish a ground game. But try the Jaguars must. San Francisco is giving up 106.7 yards per game on the ground, but RB Maurice Jones-Drew will still struggle to find many running lanes behind Jacksonville's massively overmatched offensive line. QB Chad Henne gets the start, and he'll likely again be forced to chuck it downfield in a desperate attempt to catch up. San Francisco has gotten back to its power ground game and will feature RB Frank Gore steadily wearing down the league's worst run defense. The key for QB Colin Kaepernick? Be smart with the ball, let the ground game do the heavy lifting and don't give the Jaguars any sparks of momentum to chew on.
*Matchup to watch - 49ers RB Frank Gore vs. Jaguars MLB Paul Posluszny: Posluszny is a tackling machine - he has 33 percent more than anyone else on the team. Unfortunately, many of those come in garbage time with opponents winding down the clock. Posluszny can play a key role in helping keep the game respectable as long as possible as he'll see a steady diet of Gore and the 49ers' strong inside ground game.
*Player spotlight - 49ers CB Tramaine Brock: The fourth-year player is steadily emerging as one of the league's top cover men. He has three interceptions and four pass breakups over his past four games, and will get a chance to rack up more stats with the Jaguars likely playing from behind.
*Fast facts: The 49ers have scored 30-plus points in each game of their four-game winning streak. ... Henne has consecutive 300-yard passing games.
WHO WILL WIN AND WHY
The long road trip is good for some sightseeing and perhaps some team bonding, but the matchup is an ugly one. San Francisco is one a four-game tear and won't let up as it tries to chase down Seattle in the NFC West.
*Our pick: 49ers 37-17