The Rattlers (12-16, 7-7 Mid-Eastern Athletic Conference) took a 54-32 lead over the Tigers at halftime, getting at least 50 points in each half.
It was the second time this season Florida A&M had reached the century mark. The Rattlers defeated Florida Memorial 100-82 on Nov. 30.
Florida A&M returns to MEAC play with two regular-season games remaining, playing at Morgan State before coming home to face Bethune-Cookman.
Edward Waters is an NAIA school in Jacksonville, Fla.