Ferrer trailed 3-0 in the opening set before rallying in the tiebreaker, then fell behind 4-1 in the second before taking control in the final two sets.
Mannarino appeared to be more adversely affected by the hot temperatures and had a visit from the tournament doctor in the fourth set.
The Spanish baseliner has lost to Djokovic in the last two Australian Opens, in the semifinals last year and the 2012 quarterfinals.
- Sports & Recreation
- David Ferrer
- Adrian Mannarino
- Novak Djokovic