Manchester United defender Jonny Evans will travel to Romania for the Champions League match against CFR Cluj but Michael Carrick, Antonio Valencia, Paul Scholes and Ryan Giggs are all missing from the Red Devils' squad.
Evans had been a fitness worry for Sir Alex Ferguson, having needed to be helped off at the end of the 3-2 defeat against Tottenham on Saturday, but the Scottish manager later claimed that the Northern Irishman was only suffering from a dead leg.
The center back trained on Monday morning at the club's Carrington complex but both Carrick and Valencia missed the session, with the latter having missed the match against Spurs with an ankle injury.
Veteran midfielders Scholes and Giggs, meanwhile, appear to have been rested despite Ferguson's insistence that he would select an experienced side.
Youngsters Scott Wootton and Michael Keane both worked out with the first team on Monday, as did new signing Alexander Buttner, but Nemanja Vidic, Chris Smalling and Phil Jones face lengthy absences.
Ashley Young, meanwhile, did not take part in the main session but worked with fitness coaches away from the rest of the squad having suffered a cartilage injury in late September.
Former United defender Mikael Silvestre was also present and training, with the former France international searching for a new club after leaving Werder Bremen. The 35-year-old is working with the Red Devils to maintain his fitness levels.
Manchester United squad to face CFR Cluj: De Gea, Lindegaard, Buttner, Evans, Evra, Ferdinand, Michael Keane, Rafael, Wootton, Anderson, Cleverley, Fletcher, Lingard, Nani, Powell, Tunnicliffe, Hernandez, Kagawa, Rooney, Van Persie, Welbeck.
Follow GOAL.COM USA on Twitter