Lyon manager Remi Garde has no fresh injury concerns ahead of Les Gones’ second-leg clash with Tottenham, though Yoann Gourcuff (hamstring) remains sidelined.
Steed Malbranque was not in the squad for Lyon's 4-0 win over Bordeaux on Sunday, while his replacement, Clement Grenier, grabbed two goals and an assist which could see him start against Spurs.
Tottenham is without its top scorer in the Europa League Jermain Defoe (ankle), while Younes Kaboul (knee) is still several weeks away from returning to first-team duty.
With Tom Huddlestone (knee) a doubt for the match and Brazilian enforcer Sandro (also knee) out for the remainder of the season, Scott Parker and Mousa Dembele are likely to continue in midfield.
Andre Villas-Boas may rotate his squad with one eye on Monday night's Premier League clash with West Ham, so Steven Caulker and Kyle Naughton could slot back into the defense.
Spurs' Portuguese boss has opted to rotate his goalkeepers in Europe, which means Brad Friedel is likely to start and thus deny ex-Lyon shot-stopper Hugo Lloris a reunion with his former club.
DID YOU KNOW?
Lyon has beaten Tottenham at home before, securing a 1-0 win over Bill Nicholson's Spurs in the 1967-68 European Cup Winners' Cup first leg – a replica of that scoreline on Thursday would send the French side through.
That 1-0 win over Tottenham was Les Gones' last home win over an English side, over 46 years ago. It is also the club's only home win over English teams, having drawn five and lost one of the other six encounters.
Lyon has won its last four European home games, recording victories in all three of its Europa League group games at the Stade de Gerland this year and beating APOEL in the last 16 of last season's Champions League.
Les Gones have averaged more shots at home in the Europa League, 20.3 per game, than any other side, with 39.3 percent of those on target. By comparison, Spurs have averaged just 3.3 shots on target per Europa League away match.
The French club is managed by Remi Garde, who spent three years at Tottenham's fierce rivals Arsenal between 1996 and 1999 (and signed for the club on the same day as Patrick Vieira).
Tottenham is unbeaten in Europe this year after seven matches, recording four wins and three draws. The White Hart Lane outfit has progressed to the next round in 46 of the 49 occasions where it has taken a first leg lead in European competition.
Gareth Bale's two free kicks at the end of either half handed Spurs victory over Lyon in the first leg.
The 23-year-old became the first Tottenham player since Robbie Keane to score an injury time winning goal in Europe, with the Irishman having struck in the 91st minute in a 3-2 win over Braga in March 2007.
Emmanuel Adebayor (pictured) spent seven years in France with Metz and Monaco. In his six games against Lyon, including the match at White Hart Lane, he has failed to record a single goal or assist. The only team he has faced more times than Lyon without scoring against is Sunderland (eight without a goal).
Spurs are unbeaten in their last four Europa League away matches, though they have not won away since beating Shamrock Rovers 4-0 in December 2011. Of the side that claimed victory over the Dubliners, only Benoit Assou-Ekotto, Harry Kane and Jake Livermore are still at the club and fit to play against Lyon.