TORONTO (AP) -- Edwin Encarnacion, Colby Rasmus and Yunel Escobar homered off Detroit newcomer Anibal Sanchez, leading the Toronto Blue Jays over the Tigers 5-1 Saturday.

The Tigers have lost three straight and four of five after a five-game winning streak that briefly lifted them into first place in the AL Central.

Sanchez, acquired from Miami earlier in the week along with infielder Omar Infante, gave up five runs and eight hits in six-plus innings in his Detroit debut.

Sanchez (5-8 overall) lost to Toronto for the second time this season; he gave up six runs in 3 1-3 innings of a 12-5 loss on June 22 while pitching for the Marlins.

Henderson Alvarez (7-7) pitched seven innings for the win.