Elon (14-11, 7-3 Southern) jumped to an 8-2 lead, but Georgia Southern came back on a 12-2 run, and led by seven on a 3-pointer by Brian Holmes. Elon's Kevin Blake capped a 7-0 run with a dunk to tie it at 25, and the Phoenix finished with an 8-2 run to lead 35-32 at halftime.
Georgia Southern took a 39-37 second-half lead on a trey by Jelani Hewitt and pulled ahead 51-45 on a jumper by Holmes. Elon closed to within two on a free throw by Ryan Winters, and then Isenbarger hit his 3-pointer with 2 seconds left.
Isenbarger finished with 10.
Hewitt led Georgia Southern (11-14, 4-6) with 20, Kyle Doyle scored 12 and grabbed 10 rebounds, and Angel Matias had 10 boards.
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