While trying to bounce back from a rough outing, Cain will also look to lead the Giants to an eighth consecutive home win and a season-high fifth in a row overall Tuesday night as he opposes the red-hot Patrick Corbin.
San Francisco (13-7) improved to 9-1 against the NL West by rallying for a 5-4 victory in Monday's series opener at AT&T Park. Buster Posey hit a tying two-run homer in the eighth inning, and Brandon Belt singled in the winning run in the ninth.
"There's no quit in this team. I can tell you that," pitcher Ryan Vogelsong said. "We fight 'til the last out. It's pretty fun to watch."
Cain (0-2, 7.15 ERA) will try to help his team register its 10th consecutive win against a division foe while earning his first of the season. The right-hander, though, could use a far better performance than in his most recent game.
Cain gave up seven runs - including three two-run homers - in his first three innings Thursday in Milwaukee before making it through the next three unscathed.
"I will say, Cain gave us a gutty effort," manager Bruce Bochy said. "He regrouped and made a nice adjustment. He pitched great the last three innings. But, when you give up three two-run homers, that is hard to overcome."
Cain has alternated between effective and miserable performances in his four starts, but he's been sharp in his last three against Arizona (10-9), going 3-0 with a 1.00 ERA. He yielded four hits and a walk while striking out six over seven innings in the most recent, a 6-0 home win Sept. 26.
Cain, though, might have to outduel Corbin (2-0, 1.42) in this outing. The left-hander continued his excellent start Thursday at New York, giving up a solo homer, a single and three walks while striking out seven over seven innings.
That 6-2 win in 12 innings is one of only two so far on Arizona's nine-game road trip, which concludes Wednesday.
Corbin gave up six runs over three innings in his most recent visit to AT&T Park, a 7-3 loss Sept. 27. He was 2-0 with a 3.15 ERA in his first three starts against the Giants.
Marco Scutaro and Hunter Pence each hit two-run homers off Corbin in that September win. Pence is 3 for 8 against Corbin and Posey, who has two homers and five RBIs in the last two games, is 4 for 11.
Wil Nieves is 4 for 6 with two doubles against Cain.
The Giants haven't won eight straight at home since a nine-game streak May 6-22, 2011, which included a sweep over Arizona.
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- Arizona Diamondbacks
- San Francisco Giants
- Matt Cain
- Patrick Corbin