With the top spot in the group up for grabs and a potentially difficult clash against Spain to avoid, both Cesare Prandelli and Luiz Felipe Scolari are unlikely to make too many changes as they seek three valuable points.
Having picked up yellow cards against both Mexico and Japan, Daniele De Rossi is suspended for the Azzurri while Andrea Pirlo is ruled out with a calf injury.
Claudio Marchisio and Alberto Aquilani are likely to deputize in the duo's absence whilst Prandelli must also decide who to play behind Mario Balotelli.
The 55-year-old coach could opt to rest Emanuele Giaccherini with Stephan El Shaarawy, Alessandro Diamanti and Sebastian Giovinco, who scored the winning goal against Japan, all vying for starting berths.
As for Brazil, David Luiz has been declared fit to start despite breaking his nose in the 2-0 win over Mexico and there is further good news for the Selecao as the in-form Neymar has shaken off a slight thigh injury.
However, Paulinho is unlikely to be risked by Scolari after the Corinthians midfielder suffered a minor ankle sprain and his place could be taken by Lazio's Hernanes.
Elsewhere, Hulk has failed to impress in the opening two matches and his spot on the right wing could be taken by PSG youngster Lucas Moura as Scolari looks to give some of his younger players international experience.