Freeney is out with a sprained left ankle. Collie and right tackle Winston Justice will both miss the game with concussions. Left guard Joe Reitz will miss his second straight game with an undisclosed knee injury.
Quarterback Chandler Harnish, running back Delone Carter and linebacker Pat Angerer also are inactive for Indy (0-1).
Minnesota has put quarterback McLeod Bethel-Thompson, receiver Jarius Wright, defensive backs Josh Robinson and Robert Blanton, linebackers Marvin Mitchell and Audie Cole and offensive guard Mark Asper on the inactive list. The Vikings made no lineup changes.