INDIANAPOLIS -- With the game on the line, Donald Brown showed why the Indianapolis Colts elevated him to starting running back.
The fifth-year back who wrestled the job from Trent Richardson ran six times for 46 yards and a touchdown on the decisive drive to help the Colts defeat the Tennessee Titans 22-14 on Sunday afternoon.
Brown had eight carries for eight yards in the game before providing the spark during an 11-play, 92-yard drive that burned 6:12 off the clock. His 4-yard touchdown run with 1:56 remaining left the Titans in desperation mode.
Tennessee had a chance to answer in the final minute, but Indianapolis linebacker Jerrell Freeman intercepted Tennessee quarterback Ryan Fitzpatrick to end the threat.
Indy's Adam Vinatieri made five field goals and Cassius Vaughn, a cornerback who had intercepted just three passes in his four-year career before Sunday's game, picked off Fitzpatrick twice. Andrew Luck passed for 200 yards for the Colts (8-4).
Fitzpatrick passed for 201 yards and a touchdown and ran for 54 yards and the Titans' other touchdown in the second quarter, but he threw three interceptions and lost a fumble. Running back Chris Johnson rushed for 69 yards and had 32 yards receiving and a touchdown for the Titans (5-7).
In the first quarter, the Colts converted a fourth-and-1 to keep a drive alive, then Vinatieri made a 47-yard field goal to give Indianapolis a 3-0 lead.
Vinatieri hit a 48-yard field goal later in the quarter to bump Indy's lead to 6-0.
Tennessee pulled ahead with a 1-yard quarterback sneak by Fitzpatrick and the extra point in the opening minutes of the second quarter.
Vinatieri answered with a 45-yard field goal to put Indianapolis up 9-7 early in the second quarter.
The Titans were moving the ball and trying to work their way into field goal range when Vaughn intercepted a pass by Fitzpatrick in the final minute of the first half.
The Colts, facing a third-and-17 at their 46 with 7 seconds left in the half, caught a break. Luck connected with receiver T.Y. Hilton for 20 yards and Tennessee linebacker Moise Fokou hit Luck in the back after he released the ball to tack an extra 15 yards onto the end of the play. Vinatieri's 37-yard field goal as time expired in the first half gave the Colts a 12-7 lead at the break.
Tennessee took the opening possession of the third quarter and faced a fourth-and-goal from the Colts' 1-yard line when Fitzpatrick found Johnson in the end zone for the score. The 14-play, 80-yard drive took 7:31 and gave the Titans a 14-12 lead.
Tennessee was in scoring range again when Colts linebacker Robert Mathis sacked Fitzpatrick and forced him to fumble. Freeman recovered and ran it back to the Tennessee 32-yard line. Vinatieri's fifth field goal, this one from 49 yards, gave the Colts the lead at 15-14.
NOTES: Tennessee TE Craig Stevens (concussion) and WR Damian Williams (hip) were inactive. Colts inactives were ILB Kavell Conner (ankle) and CB Greg Toler (groin). ... The Colts lost to St. Louis 38-8 in their previous home game, one of their worst home losses ever. ... The Colts entered the game with an 8-0 record under coach Chuck Pagano following a loss. ... Colts K Adam Vinatieri became the second NFL kicker to score at least 800 points with two different NFL teams. Morten Andersen was the first player to accomplish the feat. Vinatieri also has scored 100 or more points 16 times in his career, tying an NFL record. ... Titans TE Delanie Walker took a hard hit late in the first quarter and missed the rest of the game with a concussion.