Some are labeling this a trap game for the undefeated Chiefs, who have a bye and a matchup with their AFC West rival Denver Broncos coming up over the next two weeks. But Kansas City has the look of a team not willing to ignore any opponent, so a loss here would mean Buffalo would have earned it.
Here are a few things to follow during Sunday afternoon's contest.
When: Sunday, November 3 at 1:00pm EST on CBS
Where: Ralph Wilson Stadium in Orchard Park, New York
Players to Watch: Eric Berry and Steve Johnson
Key Matchup: Chiefs pass rush vs. Bills pass protection
Chiefs Bold Prediction and Fantasy Beast: Dwayne Sets Season Highs in Catches, Receiving Yards and Touchdowns
Sooner or later, Bowe is going to have a game that reminds everyone why the Chiefs handed him such a handsome contract in the offseason. And Sunday's matchup with the Bills could finally be his breakout performance of 2013.
Buffalo's defense ranks 24th in the NFL by allowing 263.4 passing yards per game, and has given up a league-worst 20 touchdowns through the air. The Bills have also yielded a combined 41 receptions for 709 yards and eight scores to their opponents top pass-catching threat through eight games.
While Bowe ranks second on the Chiefs in receptions and third in receiving yards, no one would question that he is indeed Kansas City's No. 1 option not named Jamaal Charles.
Bowe's season highs are five receptions, 66 yards and one touchdown. He has an opportunity to surpass each of those numbers against Buffalo.
Bills Bold Prediction: Two Quarterbacks Throw 15-Plus Passes for Buffalo
The quarterback carousel continues in Buffalo this week with the only guarantee being that rookie E.J. Manuel will not be available against the Chiefs. As for Thad Lewis, Jeff Tuel and Matt Flynn, who knows who will be taking the majority of the snaps for the Bills.
It looks as though Lewis is expected to be the starter, but questions surrounding his health could either change that or create a short-leash situation on Sunday. As often as the Chiefs have been spending in the backfield this season terrorizing opposing quarterbacks, the Bills might just be forced into using more than one signal-caller.
Fantasy Bust: C.J. Spiller
Hampered by a high-ankle sprain for much of the season, Spiller missed his first game last week in a loss to the New Orleans Saints. And his status against the Chiefs on Sunday is considered day-to-day.
Though some of the blame can be put on the running back not quite being 100 percent, Spiller has failed to produce at the level most expected him to this season. He has just 392 yards and one touchdown on 90 carries.
With Fred Jackson healthy and playing well, the Bills will not feel as pressured to get Spiller involved as much -- which should make owners shy away from starting him if they have better options. And with Kansas City allowing just 103.3 rushing yards per game and two touchdowns on the ground, the matchup would not make you second guess the decision.
Assuming Spiller is active this week, steer clear. And if he does not end up playing, his status as fantasy bust of the year is only heightened.
Jeremy Sickel has successfully created and operated numerous websites. His work can be read on Yahoo and Bleacher Report, and he has also appeared on various podcasts and sports talk shows around the country. Interact with Jeremy on Twitter @JeremySickel
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