Charlotte (15-13, 6-9 Conference USA) shot 52 percent from the floor. Marcus Bryan added 10 points and Pierria Henry had 10 assists to go with seven points. The 49ers held a 35-25 rebounding advantage and had assists on 21 of their 30 baskets.
Charlotte used a 14-4 run in the middle of the first half - six by Clayton - to lead 32-26 at the break.
The 49ers went up by 17 points just over 7 minutes after intermission on Shawn Lester's 3-pointer, and kept ODU at arm's length the rest of the way.