The 49ers went on an 18-3 spurt early in the second half after trailing 42-41, and the Colonials never mounted a serious comeback the rest of the way.
The victory moved Charlotte (13-13, 5-8) closer to securing a spot in the Atlantic 10 Conference tournament after the teams came into the game tied for 11th place in the conference standings. It also was revenge after George Washington (9-18, 4-9) won 60-52 at home in January.
DeMario Mayfield added 15 points and nine rebounds for Charlotte.
- George Washington