Isaiah Sykes and Keith Clanton added 14 points each for the Golden Knights (6-2), and Sykes contributed seven rebounds, seven assists and five steals.
Old Dominion made more field goals (25-24) and 3-pointers (9-8) than Central Florida, but the Golden Knights outscored the Monarchs from the foul line 19-12.
The Monarchs took their only lead of the game at 51-50 on Dimitri Batten's free throws with 11:44 remaining, but Sykes' layup pushed the Eagles' advantage to 54-51, and ODU could never catch up.
Richard Ross' layup cut it to 71-69 with 23 seconds left, but Tristan Spurluck and Sykes made two free throws each to close out the game.
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