Mathieu, having a sensational season at safety and several other defensive back positions, returned the free kick following a Rams safety and was buried in a pile of Ram tacklers.
As he jogged off the field, the knee buckled and Mathieu collapsed on the ground. A cart immediately was called and he was carried off the field.
Arizona drafted the ''Honey Badger'' in the third round after he spent a year away from football following his dismissal from the LSU team for marijuana-related problems.
He quickly became an Arizona fan favorite.
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