DENVER - Peyton Manning threw three of his four touchdown passes in the second half, and the Denver Broncos ran off 38 straight points to rally past the Washington Redskins 45-21 on Sunday.
Manning, playing on a sore ankle, completed 30 of 44 attempts for 354 yards passing in helping the Broncos (7-1) bounce back from their only loss of the season last week in Indianapolis and spoiling Redskins' coach Mike Shanahan's homecoming to Denver.
Shanahan, who won two Super Bowls in 14 years as the Broncos' coach, was honored in a pre-game video tribute.
His new team had the upper hand for a while -- Washington led 21-7 -- before being broken down under a withering offensive comeback and relentless defensive pressure by the Broncos.
Robert Griffin III left the game with about four minutes remaining after a hit by 335-pound defensive tackle Terrance Knighton, who came down on Griffin's left knee. Medical personnel rushed to the field to tend to Griffin and examined his left knee quickly on the sideline. The team announced he was being held out of the game as a precaution.
Kirk Cousins finished up and threw a pair of interceptions, including one that Dominique Rodgers-Cromartie returned 75 yards for a touchdown.
Griffin, who took one hit after another, finished 15 of 30 passing for 132 yards, with a touchdown, two interceptions and a fumble for the Redskins (2-5).
Down by two touchdowns early in the third quarter, the Broncos sluggish offense roared back to life, running off 38 straight points to regain the lead even as Denver's defense turned up the heat on Griffin and the Redskins' attack.
Manning regrouped to lead a long drive ending in rookie Montee Ball's first career touchdown run, a 4-yarder with 7:48 remaining in the third quarter.
On the first play of the fourth quarter, Manning finished off another drive with a short scoring pass to Joel Dreessen as the Broncos drew even 21-all.
A special teams mistake opened the door to the Broncos' go-ahead score. Sav Rocca shanked a punt that traveled only 15 yards to the Redskins' 35, and on the next play, Knowshon Moreno took a screen pass from Manning all the way to the end zone.
Von Miller, playing in his second game since returning from a six-game suspension, sacked Griffin and forced a fumble that was recovered by Derek Wolfe at the Washington 24, leading to Matt Prater's 19-yard field goal.
Chris Harris, subbing for the injured Champ Bailey, made a diving interception of a Griffin pass that was intended for Pierre Garcon at the 25. After a holding call set the Broncos back, Manning found Demaryius Thomas for a 35-yard touchdown pass that extended Denver's lead to 17 points.
Washington broke away for a 21-7 third quarter lead, scoring a pair of touchdowns nine seconds apart, both following turnovers by Manning.
Defensive lineman Ryan Kerrigan had a strip-sack of Manning and linebacker Brian Orakpo recovered the loose ball at the Broncos' 19-yard line. Alfred Morris took over from there, with three consecutive runs, the last a 1-yard score.
Washington struck again on Denver's next play. Demaryius Thomas slipped and fell as Manning threw him a pass, leaving DeAngelo Hall in position for the interception and 26-yard return down the left sideline for the touchdown.
The Broncos, held to a season low in points over the first two quarters, were tied with Washington 7-7 at halftime, giving life to the Redskins' equalizing drive when they were flagged for having too many men on the field as Washington lined up for a field goal try.
With a first-and-goal at the 7 after the penalty, Griffin found Leonard Hankerson in the end zone for the touchdown pass with 19 seconds left in the second quarter.
Denver opened the game impressively, marching down the field on their opening possession before Manning connected with a wide open Wes Welker from 6 yards out for the touchdown.
NOTES: Denver has 343 points in eight games, an NFL record. The Broncos set a team record with 31 fourth-quarter points. ... Broncos RB Ronnie Hillman, who had a goal-line fumble in last week's loss at Indianapolis, was among the team's inactive players and watched the game in street clothes from the press box. ... Also inactive for Denver was CB Champ Bailey, who last week aggravated a foot sprain that forced him to miss the first six games of the season. ... Washington safety Reed Doughty was held out of the game because of a concussion suffered in last week's victory over Chicago. Washington also was without safety Brandon Meriweather, who served a league-imposed one-game suspension for a helmet-to-helmet hit against the Bears. ... Washington defensive end Kedric Golston left the game in the third quarter with a shoulder injury.