TORONTO -- J.P. Arencibia and Colby Rasmus hit home runs and left-hander J.A. Happ allowed one hit in 5 1/3 innings Saturday as the Toronto Blue Jays held the Boston Red Sox to two hits in a 5-0 victory before 45,797 fans at Rogers Centre.
The only Red Sox hits were a double by Jacoby Ellsbury to lead off the game and an infield single by Dustin Pedroia with two out in the ninth.
Rasmus caught Mike Napoli's drive at the wall in center field to end the game.
The Blue Jays had eight hits.
The Red Sox (3-2) lost starter John Lackey (0-1) in the fifth inning because of a right biceps strain. It was his first start since 2011 after undergoing Tommy John surgery on his right elbow.
Happ (1-0) allowed one hit and three walks while striking out six. Steve Delabar pitched 1 2/3 innings, Aaron Loup pitched the eighth and Sergio Santos pitched the ninth to shut down the Red Sox.
The teams play the rubber match in the three-game series on Sunday.
Blue Jays first baseman Edwin Encarnacion cut down Pedro Ciriaco at home plate in the third inning on Ellsbury's grounder into the drawn-in infield.
Ciriaco had walked with one out and reached third on a wild pitch and a throwing error by Arencibia.
The Blue Jays (2-3) couldn't produce anything from a two two-out singles in the third.
Happ struck out the side in the fourth. Arencibia hit this third home run of the season in the bottom of the fourth after Adam Lind snapped his 0-for-14 drought with a single.
It was the first time this season that the Blue Jays scored first in a game.
Lackey left the game with one out in the fifth after he grabbed his arm following a pitch that sent Jose Reyes sprawling to put the count at 3-and-2.
Alfredo Aceves replaced him and threw ball four, with the walk charged to Lackey, who allowed five hits, one walk and two runs while striking out eight.
Rasmus' second homer of the season was a shot to center and put Toronto into a 5-0 lead with one out in the bottom of the sixth.
Lind led off with a walk and took second with his sixth career stolen base, Mark DeRosa walked before Rasmus connected on a 2-and-0 fastball.
NOTES: The Blue Jays designated for assignment right-handed reliever Jeremy Jeffress and bought the contract of right-hander Dave Bush from Class-AAA Buffalo. ... Right fielder Jose Bautista of Toronto (right ankle) did not start Saturday for the second game in a row. ... Red Sox shortstop Stephen Drew, who has been on the seven-day concussion disabled list since March 28, was 1-for-3 with a double and an RBI on Friday in the second game of his rehabilitation assignment with Class AA Portland. ... Boston shortstop Jose Iglesias who left Friday's game because of a bruised arm after being hit by a pitch, did not start Saturday's game. ... Catcher Henry Blanco is scheduled to make his first start for Toronto on Sunday, when he catches knuckleball pitcher R.A. Dickey (0-1, 4.50 ERA), who opposes left-hander Jon Lester (1-0, 3.60 ERA). ... Jose Reyes hit a first-inning single on Saturday and has reached base safely leading off the game in all five games.